About the project
Project Manager
Otarbayev Bauyrzhan
Candidate of Veterinary Sciences, Associate professor
Scopus Author ID: 58040625900
Researcher ID: rid138622
ORCID: 0000-0002-8280-367Х
Relevance
Parasites infect hundreds of millions of people, causing substantial levels of disability and mortality and resulting in devastating social and economic consequences. However, alongside the emergence of adverse effects of chemical acaricides—such as toxicity, environmental pollution, and persistence—growing efforts are now being directed toward developing new agents to combat parasitic diseases. Natural products (NP) and their derivatives have come into the spotlight of the scientific community. In this project, lead compounds will be obtained by optimizing the structures of NP isolated from medicinal plants in Kazakhstan, using methods from phytochemistry, medicinal chemistry, molecular biology, and parasitology.
Aim
The aim of the project is to identify 8–10 active natural compounds from medicinal plants, then obtain 2–3 lead compounds with promising acaricidal and anti-tick activity, as well as develop 1–2 candidate drugs for the creation of new antiparasitic agents; ultimately, a drug for clinical use will be developed.
Expected and Achieved Results
We will conduct a comprehensive study and analysis of the traditional use of medicinal plants in Kazakhstan and screen medicinal plants for antiparasitic activity. Active ingredients from medicinal plants will be extracted using various solvents to obtain water-soluble and lipid-soluble components, respectively, then lyophilized and preliminarily evaluated for the anti-tick biological activity of each component. Extracted components with strong antiparasitic activity will be further screened and confirmed using liquid chromatography–mass spectrometry analysis and high-performance liquid chromatography. As a result, lead anti-parasitic compounds—namely, 1–2 anti-tick candidates—will be obtained.
Information for Potential Users
This project follows a widely used global drug-development strategy aimed at discovering antiparasitic natural products and creating new antiparasitic drugs based on medicinal plant resources. The advantage of this project lies in the fact that Kazakhstan’s unique medicinal plant resources have not yet been fully explored and developed. Therefore, comprehensive investigation of these resources and the development of new antiparasitic drugs are of great importance for supporting the livestock industry in Kazakhstan.
Project Team
1. Ilgekbaeva Gulnaz
Doctor of Veterinary Sciences, Professor
Scopus Author ID: 8584173700
Researcher ID: C-3945-2013
ORCID: 0000-0001-7140-2961
2. Dutbaev Yerlan
Candidate of Agricultural Sciences, Associate Professor
Scopus Author ID: 57191979638
Researcher ID: AAS-6955-2020
ORCID: https://orcid.org/0009-0004-0484-7601
3. Alimov Aitbai
Candidate of Veterinary Sciences, Associate Professor (Docent)
Scopus Author ID: 57220068059
ORCID: https://orcid.org/ 0000-0003-1028-0408
4. Turganbayeva Gulnar
Candidate of Veterinary Sciences, Associate Professor
Scopus Author ID: 57222901565
Researcher ID: LKN-6138-2024
ORCID: https://orcid.org/0000-0002-2400-508X
5. Sabyrbekova Shynar
Master of Veterinary Science
ORCID: 0000-0002-6290-8474
6. Daniyal Ayaulym
Master of Veterinary Science
ORCID: 0000-0003-4504-3795
7. Zanilabdin Makpal
Academic degree, title: Master of Veterinary Science
ORCID: 0009-0000-6710-2368
8. Valieva Bayan
Bachelor’s degree holder
ORCID: 0009-0004-2263-0940
9. Bolatbekuly Nurym
Bachelor’s degree holder
ORCID: https://orcid.org/0009-0004-1987-3466