About the project
Project Manager
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Kuantar Alikhanov Ph.D Scopus Author ID: 57216655567 ORCID: 0000-0001-9514-7678 Relevance In the country's dairy cattle breeding, there is an acute problem of increasing the number of livestock, increasing the level of milk yield, and improving the quality of the milk produced. It is also considered essential to carry out measures to reduce inflammation of the mammary gland. Unfortunately, despite active measures taken in recent years to treat and prevent inflammation of the mammary gland (mastitis), there is still a high percentage of animals with mammary gland dysfunction in the herd. Inflammation of the mammary gland in cows - mastitis - is the main reason for the decrease in milk yield, sanitary and technological qualities of milk, and premature culling of animals. The wide distribution of mastitis in cows and the tremendous economic damage it causes to the country's livestock production make this problem one of the most critical tasks of modern veterinary science. Considering this, scientific research is being conducted worldwide to develop diagnostic, preventive, and therapeutic measures to reduce the incidence of mastitis in cows. However, despite the constant improvement of means and methods of combating mastitis, mammary gland inflammation (mastitis) in recent years remains the most common disease in cows on dairy farms and complexes worldwide. The economic damage is further aggravated by the fact that as a result of treating cows with mastitis with drugs, the time frame for milk rejection increases, limiting its use for human nutrition. The severity of the inflammatory process influences the degree of changes. Animals are susceptible to the disease during lactation, but it is most often observed in highly productive cows. There are various diagnostic methods and many drugs for treatment and prevention today, but cow mastitis is still widespread. The effectiveness of several therapeutic drugs, especially those containing antibiotics, is gradually decreasing; therefore, it is necessary to find new ones. In addition, after using many anti-mastitis drugs, milk has to be rejected for a long time due to the presence of residual amounts of antibiotics in it. Thus, there are still no reliable methods for protecting cows from mammary gland inflammation. It is necessary to carry out more advanced preventive measures, including regular identification and treatment of sick animals, adherence to strict measures for milking technology, reliable disinfection of milking equipment before milking, and sanitary treatment of udder teats with adequate preparations after milking. One of the factors influencing the quality of raw milk produced is the improvement of early diagnostic measures to prevent inflammation of the mammary gland of cows, determining the genetic potential of resistance to mastitis, and creating the possibility of using effective measures that increase the socio-economic effect. Therefore, to prevent inflammation of the mammary glands of cows and carry out timely therapeutic measures, it is essential to improve the various methods developed to date and increase their effectiveness. Project objective The goal of the project is to develop and improve methods for preventing inflammation of the mammary gland in cows and improving the quality of milk, timely and effective treatment of sick animals, restoring the physiological function of the udder and maintaining high productivity of cows. Expected and achieved results Expected results of the project: 1. A comparative analysis of milk productivity, quality, and technological properties of milk from healthy cows and those who have recovered from various forms of mastitis will be carried out; 2. Work will be carried out to search for DNA markers of resistance to mastitis in cows and genotype cows at gene loci associated with resistance to mammary gland pathologies; 3. An effective remedy will be developed for sanitizing the udder and treating mastitis in cows; 1 utility model patent application of the Republic of Kazakhstan and 2 articles in journals recommended by Committee for Quality Assurance in Science and Higher Education (CQASHE) will be submitted. 4. The influence of veterinary and sanitary measures in preventing mastitis and their impact on the sanitary quality of milk produced will be determined. Two articles and/or reviews will be published in peer-reviewed scientific journals indexed in Science Citation Index Expanded database Web of Science and (or) having CiteScore percentile in Scopus database not less than 35 (thirty five). Information for potential users The target consumers of the results obtained are all dairy farms (large, medium, small, family, etc.) that produce whole milk on a national scale. The developed means for udder sanitation and mastitis treatment will make it possible not only to prevent mastitis, their use also affects animal productivity, food safety, etc. The results of the study will be successfully applied at veterinary inspection facilities and will ensure effective mastitis prevention and product safety. Members of the research group Ibragimov Primkul Doctor of Veterinary Sciences, Professor Scopus Author ID: 57191537197 ORCID: https://orcid.org/0000-0001-6720-3396 Alpysbaeva Gulmira Candidate of veterinary science, professor ORCID: https://orcid.org/0000-0003-1504-3989 Barakhov Bakhyt Candidate of veterinary science, Associate Professor Scopus Author ID: 7191537197 ORCID: https://orcid.org/0000-0003-3302-8707 Narbaeva Dinara Master of Veterinary Sciences, Senior Researcher Scopus Author ID: 7191280129 ORCID: https://orcid.org/0000-0001-7201-4434 Turabekov Manas Master of Veterinary Sciences, Senior lecturer Scopus Author ID: 7191280129 ORCID: https://orcid.org/0000-0001-7597-8132 Ongarkulova Aigul Master of Veterinary Sciences, РhD doctoral student ORCID: https://orcid.org/0000-0002-5193-4714 Muslimova Zhadyra Master of Agricultural Sciences, laboratory assistant Scopus Author ID: 58820604900 ORCID: https://orcid.org/0000-0003-3485-7240