About the project
Relevance
More than 20 hereditary anomalies are currently found in beef cattle, but in the Republic of Kazakhstan there are no developed methods of detection of genetic defects, genetic monitoring of the population is not carried out. High level of exchange of genetic materials and large-scale use of artificial insemination of cows and heifers increases the risk of such genetic defects as Arthrogriposis multiplex, Osteopetrosis, Developmental duplication, Double muscling, Hypotrichosis, Inherited congenital myoclonus, Cardiomyopathy with wool hair, Congenital muscular dystonia type 1 in cattle. Therefore, the development of methods for detection of mutation carriers in genetic defects: Arthrogriposis multiplex, Developmental duplication and Hypotrichosis is an urgent problem of veterinary science. The scientific novelty of the project is to determine the occurrence of genetic anomalies: AM, DD, HY in beef cattle, including cows and bulls of Kazakh white-headed breed. Molecular-genetic methods of diagnostics will be optimized and alternative methods of diagnostics will be developed on the basis of studying the genetic nature of AM, DD, HY occurrence. Monitoring of the studied loci allows to determine the level of prevalence of genetic defects AM, DD, HY in Angus, Hereford, Kazakh white-headed cattle breeds. The economic effect of this project is to reduce the incidence of hereditary diseases in cattle.
Objective
Genetic monitoring of breeding stock of Angus, Hereford, Kazakh white-headed breeds of agrofirm "DINARA-RANCH" LLP, introduction of molecular-genetic methods of detection of wild and mutant types of alleles of MOCS1, NHLRC2, KRT71 genes.
Achieved results
As a result of our research, we determined the incidence of genetic defects Arachnomelia Syndrome, Developmental duplication, Arthrogriposis multiplex in the Angus breed to be 4.1%, 1.66% and 5.0%, respectively. In the Hereford breed, heterozygous carriers of only two genetic defects were identified, Arachnomelia Syndrome and Arthrogriposis multiplex, the prevalence of which was 2.5% and 1.66%.
The scientific novelty of the project is the determination of the occurrence of genetic anomalies: AM, DD, HY in beef cattle, including cows and bulls of the Kazakh white-headed breed.
Information for potential users
The results of the study allow us to conclude that the identified genetic defects must be included in the register of cattle diseases and a regulatory act should be adopted according to which genetic screening of breeding stock should be carried out covering 10-20% of the livestock at the expense of farmers.
